Long-term marijuana abuse can lead to addiction or compulsive drug seeking and abuse. Long-term marijuana abusers trying to quit have reported withdrawal symptoms such as irritability, sleeplessness, decreased appetite, anxiety, and drug craving.3 Users do develop a tolerance for the drug-that means they need more marijuana to get the high they once got with smaller doses. Studies have found that young people who regularly use marijuana are more likely to use other drugs. As a result, they run a higher risk of becoming addicted to other drugs. Studies have shown a link between long-term marijuana use and increased rates of anxiety, depression, and suicidal thoughts.